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Even if you're not using IE, keep it up-to-date. I would also recommend updating to SP3. I believe all of the initial issues surrounding people's upgrades to it have been taken care of, but as a precaution you may want to make sure that critical files are backed up. Have a plan for what to do in case something goes wrong - of course, you should ideally have such a plan in mind in case of a system failure from other causes.
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