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I am beginning to think the psycho-pass is a measurement of general brain healthiness. It can deteriorate for short periods (akin to how a diabetic that eats a cake with a six pack of beer will get his sugar level sky high) but if treated in a medical institution it will get better,but once the brains gets damaged for long periods of time, it will never return to normal.
So maybe Makishima (and Akane) are the results of genetic experiments "Hey, we need citizens whose hue never gets cloudy, that will wipe from the face of earth all criminal offenders". The moral of the story would be that albeit most crimes are committed by people whose brains are not 100% healthy (due to malnutrition, unemployment or abuse), there are still crimes that can be committed by perfectly healthy citizens, such is the downside of every human having a free will.
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