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There's no reason they couldn't once enough new manga material was generated... the manga is covering the girls last year in high school so the "new gang" would have to be the main focus of the second series. The Original Gang could make frequent appearances though as they enter college or the work force.
It just depends on the persistence of the buzz and interest in the comic and the related merchandise. I'm going to give it less than 50% though because of past observation of the anime industry. They just don't often tend to do things like that and when they do, it frequently falls flat.
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