The light novel
Ore no Imouto ga konna ni Kawaii wake ga nai will be getting a drama CD release in late March 2010.
Kirino - Taketatsu Ayana ( Azusa from K-On!, Ako from KissxSis )
Kyousuke - Nakamura Yuuichi ( Okazaki Tomoya from Clannad )
Other seiyuus are: Hanazawa Kana, Nabatame Hitomi, Satou Satomi, Hayami Saori and Tamura Yukari
http://mflatischler.tk/post/33971569...audio-drama-cd
http://dengekiya.com/p/4942330700518/
http://oreimo.dengeki.com/