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Throwing in another vote for Full Metal Alchemist: Brotherhood , that series had me reduced to tears towards the end.
Also another vote for Seirei no Moribito.
Although many may disagree, I consider Terra e.. pretty epic. It starts a little slow and there isn't much romance but the character development is amazing.
Vision of Escaflowne is dated but has all of the aspects you are looking for.
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