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If you want to narrow it down to just the drug use, since I notice that's what the discussion has been focused on, I do have an unorthodox suggestion for you.
In the mahjong gambling anime Legendary Gambler Tetsuya, there's an arc with a character who's hopelessly addicted to what I believe is meth. Naturally, this gives him something akin to superhuman powers. But he's still a complete mess, and the anime focuses strongly on the grim consequences of his addiction. The rest of the series isn't concerned with drugs, though. Might be some drinking, I can't really recall. It's an overall gritty affair.
If you want an anime with a huge amount of sex scenes and a good deal of drinking, I recommend the legendarily "so bad it's good" 90s extravaganza "Mad Bull 34." It is for a very specific audience, though. Think Troll 2 in anime form.
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