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Originally Posted by chrno_the_sinner
Is it possible that Rika injected Rena with the syringe this time around? I've always thought that Rika had the cure for the madness since she tried to use it on Shion. I don't believe that Keiichi cured Rena on friendship alone, though it was a large factor.
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Actually, that was one of the things that was left out back in episode 25. Rika visited Rena during the time when she was hiding in her 'secret hideout', just before Keiichi did. She presented the syringe to her and offered the injection. But Rena who was overtaken by her own madness, accused Rika of attempting to kill her the same way that Tomitake was murdered. Whether the syringe was a cure or not was never clearly stated, but Rika did mentioned that the substance inside was different from those used on Tomitake.
EDIT: A question to those who play the game -