Tiger and Bunny - "Barnaby Brooks Jr." is Co-Main Lead, and given his name, he's not Japanese. The setting is more "AU America" than "AU Japan" too, imo.
Heroman - American setting, American main protagonist
The various anime versions of comic book properties - X-Men, Iron Man, Wolverine. These characters all retain their original nationalities (typically American, but Wolverine is a proud Canadian like Ryouko Asakura is
).