I've never played the games so can't debate properly with that data but... my miniscule knowledge of all forms of alien tell me that normal guns don't work on those things, that or their hide is really resilient to regular ammo. Specialized bullets were required to fight back. Predators are hunters, they are equipped with only the most basic armor, but those little armor could probably take fire from a tank's cannon and barely dent in. They rely mostly on strength. Other than that they are an extremely squishy race. I'm talking about Blassreiter level mutant
They're conscious of it. I felt similar awkwardness when I realized I was borrowing the bathroom of a room which was inhabited by girls...