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I could be mistaken, but wasn't Mana shown to be already infected in every scene we saw her in? If that is so, it's entirely possible that the infection just caused a gradual degradation of her mind (and for all we know she may have always had incestuous feelings toward Shu, and being infected just made her more open to acting on them or something); just because we didn't see the entire process of her mental shift doesn't mean it was an immediate change.
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