But I think one of the main things with Orihime is that, by nature, she is "a lover not a fighter" type of person. Its not in her nature to become violent and jump at the person looking to kill them. But that in itself seems to be what a lot of people hate on her for.
Anyways, I do feel sorry for her. But I also feel sorry for the other characters that have their own problems(which makes a majority of the cast right now...XD) So, while I'm not singling her out and making her out to be "the most tragic character", I have to feel bad for her. She's a sweet and innocent person who is in a situation where that isn't very helpful, but she has a hard time being confident enough to change that about herself. And I get that her lack of self-confidence also bothers people, but think of it this way for the current situation at least:
Keep in mind that Im not trying to force you to like her. You have your opinion, I have mine, its all good.
Im just trying to show things from a different pov.