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Mana is basically magical energy in ToaruVerse. This word is normally used to refer to natural magical energy, or to magical energy created inside one's own body.
Telesma is specifically used to refer to angel's magical energy. This is different in nature to mana, with differences like potency issues. Humans can't handle Telesma inside their bodies, even saints like Acqua, since when he tried to absorb half of Gabriel's power he almost killed himself. They could redirect it to things like crosses or vessels to contain their power, if what Index said in Vol6 was right. Curtana Original I think used Telesma as well.
Bottom line, mana and telesma is like different types of fuel/petrol.
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