I would EXTREMELY, HIGHLY second
Fruits Basket(LOOK AT MY NAME). It has been and still is my all time favorite show. It's brimming with great comedy and drama in EVERY episode, and the english dub is EXTREMELY well done, which I'd personally recommend over the jp version. Seriously, WATCH THIS NOW
!!!!
Now and Then, Here and There is pretty good. It's fairly gritty though, as it mostly shows kids being used and abused as tools for war, but it's a very well done drama.
Hana Yori Dango, aka Boys Over Flowers was something I greatly enjoyed. It has a strong, independent heroine as the main protagonist, and a pompous, arrogant, but occasionally considerate rich guy, whom she butt heads with much of the time. Both the anime and the live-action TV series are very good, so either one would be enjoyable.