[Zek]

Originally Posted by Geta Boshi

Spoiler:

Have you noticed Chiruchi is Bleach's first female antagonist .With Luppi turning out to be an It .. I second Pesh's Ecchiness Chiruchi is like Rawr

If you're ruling out the shinigami, then Bleach has hardly had any antagonists at all, besides hollows. And the hollow Inoue fought way back when was female.