I think the saddest part of the ending is the fact that while Battler is still alive he became another person and doesn't even want to return to his older self, which means he can't be Ange's brother.
From one side it's comforting for Ange to know that Battler is alive and... (not so well actually...) but in the end her "Oniichan" didn't come back and never will.
It's very sad, but yes there's been sadder stuff.
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