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Please don't bring Nasu terminology and logic in Toaru, it gives weird temptations ...
We don't know for sure if IB can be altered that way, at least no one implied something like that can be done ... no, it's more like it can't be altered that way at all, otherwise the point of IB being an absolute point of reference won't make sense anymore.
The thing about it being able to kill a vampire or not is more or less a question of point of view, why does Deep Blood exist if IB can deal with them? That's just one way to see it though.
The other one Tsunade mentioned is "are they some kind of distortions?". But it's more about whether their body is made of : if it is of supernatural materials (like the Angels) or natural materials that are stabilized with some kind of magic (the rock or parer Golems) or supernaturally modified materials (like Marian's "properties"), in this case it should work. But, from what we know IB doesn't work on naturally born humans whose specs are enhanced with some kind of supernatural tricks (the saints) or oddities with natural human-like bodies like Fraulein (it doesn't look like IB work on her from what we've seen up until now) ; if the vampires are one of them, then IB won't likely work on them.
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