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Well, with Destroyer's ability to suck energy Priscilla might have some problems with regenerating. And something tells me that if Clare smacked Priscilla in the form we've seen earlier Priscilla would have to regenerate from scratch. If Isley could destroy 25% of her body with one blow I would imagine that Destroyer+Clare could do much more damage and only a pile of goo that used to be Priscilla would remain.
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