For me it actually depends on the anime, whether i found it enjoyable or not. Anyways, when it ends i feel both relieved (if the story has a good ending) and sad (because it came to an end).
Just to give out some examples:
Toradora
Zero no Tsukaima
Steins;Gate
The melancholy of Haruhi Suzumiya
PS: By "good ending" i'm not meaning only "happy".