[Bonta Kun]

Originally Posted by cyberdemon

Not necessarily.

Spoiler for Lisanna:

There's isn't any indication that it is a permanent mark. It's possible that you can remove it and put it on a different spot later on.

Spoiler:

Highly doubt that she would move her mark, if animsia was to play it's part, I don't see her moving her mark for any sorta reason. I would think she would keep it as it is, in hopes it reminds her of her past life or if someone would notice.
I just see no reason to do so and can't see Mashima coming up with a good reason either.

Big question would be is, where or what happened to the real Edo Lisanna, if this Lisanna is from earthland.