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Originally Posted by SilverSyko
But what exactly is this toxin Ange keeps referring to? I'm guessing it's lack of love or something but since Amakusa had the toxin too I could be wrong.
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The anime didn't went and explained it. This "toxin" is something all humans carry and is like when someone thinks rationally about the "supernatural". People who doesn't believe in magic carries this "toxin". Many people with this toxin around = Low chance magic can be used around them. Please someone correct me if I'm wrong.