Video game, lolz...erm...that's fine too. (Ahahahahaha! Live action video game?! That'll be the day
)
But Sass, in that case, there is no way any of these actors would work. Let alone trying to get all of them together in a single movie. Budget would go through the roof. Not even massive box office hits get this many big names in one movie, TV mini-series usually don't get even a single one
Not to mention any american-made production of Claymore would suck so badly, and most or all of the actresses listed so far have been hollywood connected.
A CG Claymore not only has a far higher chance of getting made, it also would look far more accurate and appropriate...not to mention awesome. Personally I PREFER Animated or CG to live action hands down. It's easier for me to connect to characters that aren't portrayed by a real person for some reason.