If the author wishes to continue the manga, in a lighthearthed manner, then he will certainly need a way to preserve Rea's body and mind.
The mangaka has actually specified in the story that it's a matter of days before Rea stars decomposing. He has basically two ways of acting:
1. Chihiro or someone else finds a way to prevent the decay process or the process is miraculously halted.
2. They don't find a way to prevent the process and the manga ends or takes a turn to the horror genre: Rea loses her mind and Chihiro starts a strugle for survival.
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