I think you can start watching either one of them, BUT if you plan on watching both, you will have to backtrack a lot, because the plot route takes a 180 turn when it comes to the main story. As far as that one goes, it is my opinion that FMA:B explains and develops certain characters in a near-perfect way, and because these characters are also present in the original adaptation, you might be put off by their original interpretation after having seen their roles and character in FMA:B.
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I don't know what or how much was changed
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Enough to become a different show, really...