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Uchuu Kyoudai (Space Brothers) is a realistic sci-fi anime that features a man in his 30s trying to realize his dream of becoming an astronaut. It is one of the best anime of the year IMHO.
And if you are open to coming of age drama, check out Sakamichi no Apollon (Kids on the Slope). It's gotten a lot of praise from people here and on other forums.
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