Blown up in some horrible lab accident.
Quick though, not slow and painful, out with a bang neh.
Or maybe in some catastrophic failure trying to transplant my brain into another body. That would be nice too. (Though I would be ecstatic if it did work)
But most of all...to see some hot fictional guy come right off his sexy pixelated medium so 1) my head would explode from amazement or 2) I'd drown in my own drool.