I'm not sure if this was mentioned before, but I just remembered something that hinted Beatrice's wound, back in EP3.
LAMBDA: "Because originally, you weren't even a witch, and at any time, I'll remind you what a truly shabby creature you were."
みすぼらしい存在
Well this might also refer to some kind of deformity, maybe she really is an intersex. The point is that this sentence hinted that Beatrice had something that made her look different than a normal human being.
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