Lord Genome's body was probably a cyborg/android one built by the Anti-Spirals to keep him immortal. Notice his spiral energy is red when for everyone else it is green, but when he's cloned as the Bio-Computer his energy is green again. That could be due to contamination of his spiral energy.
If Genome's makeup was simmilar to Nia's, with a mixture of spiral genes and whatever the Anti-Spirals are made of, that would have continued on into Nia, making her the next messenger.
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