Weigh your sentimental values against the profit to determine your personal answer. I'm using a semi-cheap example, but I've got the first DVD of Hikaru no Go that was my first foray into physical anime collectibles that I wouldn't ever sell. I've got a few DVDs of Fullmetal Alchemist that I looked into soon after, and while those are still important to me, I could see myself selling it if the markup was that crazy.
If you're not a serious collector, then hey, why not? It sounds like it's going for a lot. However, you should also research and gauge just how valued these things are, since they'll probably continue to increase in value as the years go by. I mean, look at stuff like Nintendo World Championships that's worth tens to hundreds of thousands of dollars today. Keep rare suckers in good condition and you're sitting on a gold mine. Of course, that's only if you don't have sentimental attachments to said product. Don't ever sell out for something you truly value.
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