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As someone who plays a lot of bot, I'd say Leona/MF is a fantastic combo.
When they both reach level 6, Leona can stun-lock the enemy while MF blasts her ult, causing lots and lots of damage due to triggering Leona's every (or at least almost) passive debuffs.
I don't play Leona with randoms though. Usually goes to hell.
Janna and Sona are pretty strong to go with anyone, so I usually go those.
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