1.) Mana drives people insane the higher the amount they have and makes witches infertile. They can't have children already and are immortal, plus they see each other as a different species.
2.) Tania and her brother have a contract with spirits of the earth from their family. They aren't witches. Likewise, there are mutants, espers, and chi-users in the series.
3.) Guinevere probably turned into one after she had Mordred or something else plot related, like her being a humonculous.
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