Quote:
Originally Posted by Ayu-ayu
Yes the minute details and origins of the pathogen are mysterious, but not a whole lot more so than, say, Ebola or AIDS are in the real world, so I can accept that it is simply a natural (albeit a bit contrived, as noted) evolved pathogen and thus isolates the supernatural part of the story merely to Hanyuu's existence and ability to manipulate time.
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I think the most implausible parts of the pathogen are its distribution and (lack of) resilience. The syndrome is extremely contagious, as a short stay in Hinamizawa is enough to for someone to become a carrier (as evidenced by Tomitake). However despite that fact it is only located in Hinamizawa. Presumably the organism is transmitted aerially (perhaps Onigafuchi swamp is the source since it gets filled in with cement after the disaster). Interpersonal transmission cannot be taking place since carriers would be able to easily spread it to others when they left Hinamizawa and it wouldn't be contained there. However in order for a microbe, whether a virus, bacterium or protist, to be able to survive in the air it has to be very robust as it has to endure both dessication and UV radiation exposure. As a result the fact it's so sensitive that it cannot survive outside of Hinamizawa doesn't make sense. Furthermore, the fact that it completely degrades almost immediately after its host dies doesn't make sense either. An organism this sensitive shouldn't be able to survive, much less act as a pathogen.
Of course the disease being localized and extremely hard to detect is necessary for the plot of the story, however Hinamizawa syndrome makes no sense from a biological perspective.