I've got such in place too, but I'm not worried about a sudden catastrophic failure. In my experiences repeated mod additions and removals can slowly corrupt and destabilize the game, and unfortunately Wrye Bash for Skyrim isn't nearly as useful as Wrye Mash was for Morrowind. The lack of a working xEdit program for Skyrim certainly doesn't help matters. Ultimately I find it safer to get the mods I want installed, then start the game and try and complete it.
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