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Orbital weapons can not transport people, can not hide by any means other than stealth technology, can not be rapidly moved to a response zone that's on the opposite end of engagement zone. Also, depending on it's orbit, said weapon may or may not be in position for firing.
If we're talking about the macross universe: orbital weapons can not engage in urban fighting (Destriod mode) or close quarters combat within a vessel. Because of their stationary nature are very susceptible from long range bombardment such as with a macross cannon.
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