Well, that or I have Tabane as final big bad, who's just as powerful as every member of the cast combined due to her omnipotence
You see, there's roughly 20 years gap between ST and the sequel. This is EXTREMELY long time in I.S. verse, because in canon, I.S. experience leap roughly 3 years once. Something like 9th generation I.S. sound plains stupid... and I can't think of further evolution except Singularity.
Therefore, I decided to place it at 6th Generation, with 7th generation being final, almost game-breaker form (Human-I.S. hybrid).
Assuming the 5th generation use that concept of yours, what would 6th Generation like?