I personally have no beef with Hirano's genki approach to Misa, who might I remind is the fangirl of fangirls in the Death Note world. She seems out of place because compared to just about every other character in DN, she's the only one who doesn't take things seriously at all. She's an amoral human who takes killing lightly (probably the only one in the series if memory serves correct), and Hirano's take on Misa reflects this to a tee. If she didn't feel out of place, then that IMO would be weird.
Just my two cents...
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