I don't think I'd ever get tired of anime. I watch almost exclusively for comedy with the odd indulgence in something with good or interesting story (or interesting art like with Tatami Galaxy). Characters' individuality and relations in the material add to the nuances of what may be recycled jokes. In my normal life, I watch lots of stand-up comedy, lots of sketch comedy, lots of sitcoms, etc, so anime is just another venue for something I frequent a lot. Heck, most of the manga I've bought are 4 koma or gag manga.
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