Especially given the infodump we've gotten the last few chapters I don't think the rules of End's world and Site's worlds are compatible. But then I guess if anyone can be badass in a parallel universe it would be Kaede, Rent-a-cop, and crew.
...as long as they aren't sperm.
It'd be nice to see Kayo and Sayaka be relevant. They've been on the bench for a while.