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As for Greed, he was killed so many times that he couldn't regenerate and he was so weakened because he died so many times. It's all connected. If Bradley could immobilize Greed then Mustang should be able to do it too, but why bother?
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Mustang doesn't know the trick about the spots, that's all. Greed could still regenerate, seeing that he just regenerated his whole body just before being stabbed by Bradley. And even after that, you can see that his body is trying to regenerate his wounds in the Homonculus' lair :
http://www.onemanga.com/Full_Metal_Alchemist/31/16/