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If you're a melee, Ryze can kite you. If you close the gap and take his E in the face, your MR will usually be in the negatives. Add to the fact that, although he is a spellcaster, his cooldowns basically never exceed 5 seconds, so it's impossible to catch him on down time late game, this only leaves him with the drawback of a very mana-intensive kit, which is why Ryze always builds ~4k mana (which also gets him offense, LAAAWL!).
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