You can certainly retain spirituality no matter how science-oriented, agnostic, atheistic, or whatever you are. You just have to be willing to discard doctrine crapola your "faith of upbringing" is carting along with it.
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"If science proves some belief of Buddhism wrong, then Buddhism will have to change. In my view, science and Buddhism share a search for the truth and for understanding reality. By learning from science about aspects of reality where its understanding may be more advanced, I believe that Buddhism enriches its own worldview." - Dalai Lama.
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