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Originally Posted by Arcion
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The failed human transmutation storyline giving birth to the Sins is the Anime's storyline (BONES' idea). The manga has a different reason and story for the Sins' creation (Arakawa-sensei's original intent & story).
Just a note. Homunculus is an artificial human. As such, the Elrics in making their mother did make a homunculus. However theirs was a failure (hence the montrosity). Any Human Alchemy in trying to create a human actually istrying to create a Homunculus.