[Renegade334]

Spoiler:

Well, now we might know why Ange snaps in the middle of battle - the ASHMB can cause some sort of cerebral/behavioral feedback. As if having a mech that seizes up every time you panic wasn't bad enough, now you have to contend with it messing with your brain? That's a very big problem right there, especially considering Rin and Simon's earlier dialogue about the Princes being naturally cocky (as they're aware of their biological superiority) and unsuited for teamwork.

Poor Asagi: first combat anxiety, now shame at being gay for five seconds or so? He'll die from a massive ulcer before the war is over.
And I guess the "toxic" treat thing raises a positive flag in Kei's favor - now she's the only character who would know how (and holds the means) to bring Izuru back to normal.