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I'm not sure it's strictly the MS that's causing Itachi's eyesight to worsen. Have you noticed that Itachi keeps his Sharingan activated nearly all the time? He only deactivates it when he's exhausted. Otherwise, even when there's no danger present, his Sharingan is constantly active. Because of his mastery over the technique and his Uchiha blood, he can probably keep it active with minimal strain on his body but the long term effects of that habit may be wearing on his eyesight.
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