Yay for Blood! It's one of the series that I'm enjoying watching the most.
As for your question about Blood: The Last Vampire; although I haven't seen it myself, a friend tells me that it's not absolutely necessary to watch it first. It would probably provide a little bit of backstory and maybe allow you to be privvy to some insider info that they talk about in the show as well. Other than that, Blood + seems to be a good standalone anime.
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