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Fullmetal Alchemist - Edward blames his father for not being there when his mother died, and hates him dearly for that.
Oreimo - Brother has a dysfunctional relationship with his younger sister. Despite the verbal and psychical abuse he still continues to help her with her problems.
Seikon no Qwasar - Boy was trained by a secret organization and nearly died from the training he had to go through. His adopted sister gave him a reason to live, but she was killed right in front of him and carries the scar of his sister figure.
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