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The usual things that make a manga different than its anime adaptation.
More detailed relationship development, more backstory, different ordering or locations of some events.
Some specific differences: no Sinclair as such and therefore less opportunity so far for Karin's girlfriend to shine like she did in the series. Anju comes across stronger and bit more calculating. Their parents are portrayed less one-dimensionally (especially Karin's mother). Grandma is *more* dangerous in a way. The way our two lovebirds are portrayed is more.... adult and frank - the potentialities are recognized pretty early even if denied.
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