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AFAIK the PIC and other barrier/shieldign systems on an IS prevent one from being hit by physical or radiation damage, but I don't think they do anything for gas, bacterial agents, or just plain old vacuum. Obviously they do a bit for high-altitude (See Silverio Gospel battle), but I think that an IS pilot surrounded by tear gas would still be affected by the gas somewhat.
To say nothing of what would happen if you threw a flashbang at an IS pilot--the enhanced vision is going to make the flash hurt.
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