Action and comedy:
Katekyo hitman REBORN! (totally hilarious! serious actions start onwards from ep 19, but it's worth the wait)
Full Metal Alchemist
Eureka Seven (ok, I know you said no very keen on mecha, but E7 is greatly similar to FMA in many ways, and is deep and hilarious too - an excellent anime in its own right)
College comedy:
Nodame Cantabile
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