(CR) Hataraku Saibou (Cells at Work!)

[Gan_HOPE326]

Originally Posted by MeoTwister5

Some oddly specific but hilariously on point observations:

1. She's probably fresh out of the bone marrow if she doesn't really know neutrophils and their brothers.

2. She couldn't go into the gate labelled "Ven" going into the lungs most likely because it means "Vein" and that was a pulmonary vein.

3. Typically that capsule would be encasing the bacteria rather than netting surrounding cells as it prevents bacteria from being captured and phagocytosed. So if we were being anally accurate, he should gone into stealth mode.

4. He is technically correct that Pneumococcus causes all of that, you'd have to be REALLY immunocompromised to have intractable sepsis in 24 hours.

By the end that epic showdown between Neutrophil and S.pneumoniae, we should all be glad that our own RBCs aren't screw ups like her, or we'd all be dead. In any normal scenario I'd be shipping Neutrophil-senpai with Erythrocyte-chan, but then I remember that most granulocytes are dead by 3 weeks.

Someone pointed out on Reddit that the whole thing where the pneumococcus hides in the RBC's load to evade neutrophiles is from a 2016 article:

http://journals.plos.org/plosone/art...l.pone.0077282

This is what sold me definitively on this series. This amount of dedication to accuracy alone is admirable.

[Anh_Minh]

Whereas I'm in it for how cute the platelets are. Sorry.

[mangamuscle]

Originally Posted by FlareKnight

I love how they are both adorable and scary efficient at their jobs. They can just casually round up all those red blood cells, stick them together, and ignore their cries with a smile. Terrifyingly adorable .

Am I the only one that see them as Tanya von Degurechaff clones? They round all of that red cells, but we are spared the scene where they all died in agony to form the blood clot >_<

It reminds me that in the ending lyrics of Yōjo Senki one of the strophes says:

Go forth! Prove that we can build
A pile of bodies that can reach the heavens!

[Mazryonh]

How dark is this anime series likely to get? There's a lot of ugly things that happen on the inside of our bodies, ranging from incurable diseases like late-stage cancer, to addiction, to organ transplantation/rejection, to deadly allergic reactions, to auto-immune disorders. Can you imagine the white blood cell characters attacking innocent cells or worse? What are we in store for?

Has this series even covered apoptosis (programmed cell death) yet? Unless the timescale of this series is very limited, we'll have to see that stuff eventually. Without apoptosis you get cancer, after all.

[Gan_HOPE326]

I imagine you could get the Killer T cells rounding up dissenters and executing them with one shot to the back of the neck before they turn cancerous...

[Dengar]

Given how this is an upbeat show, I doubt we'll be seeing anything leading to the body's death. I don't think this is a problem. I mean a tiny scrape was presented as a possibly world ending crisis.

[James Rye]

Well for tiny cells it is. Millions of cells died that day, disappearing into the abyss, tragic, really tragic~

But there is a spin-off called BLACK which is about an unhealthy body and where you see the cells getting eaten by Macrophages and red blood cells getting ripped apart by bacteria and so on.

[Gan_HOPE326]

Originally Posted by Dengar

Given how this is an upbeat show, I doubt we'll be seeing anything leading to the body's death. I don't think this is a problem. I mean a tiny scrape was presented as a possibly world ending crisis.

Guess they need to take it seriously all the time. After all, without the work from the immune system, it would be. I've had stupid stuff like toenail infections getting the doctor to just give me urgently a cycle of antibiotics just in case. Apparently there's been cases of people getting sepsis even from something like that, if untreated.

[Dengar]

That's exactly my point though. They can have many exciting episodes while still being able to save the day by the end.

[Stark700]

Episode 3:

They need more cells like macrophage. What a badass.

Thought episode 3 was pretty intense in terms of action. Influenza may be common but can also be serious left untreated. I like how they protrayed the virus like zombies for an invasion.

[blakstealth]

I hope my macrophages look like that.

[Anh_Minh]

I don't have nearly as much sympathy for Naive as I do for RBC. I mean, she may have no sense of direction, but she's never shirked her duty. And I can't help but feel he became kinda douchey on activation.

[SeijiSensei]

I wonder if there will be episodes where drugs or antibiotics are introduced into the body. How about things like "synthetic biotics," ordinary probiotics, or even vitamins? It doesn't sound like the Japanese take vitamins all that much.. Probiotics, on the other hand, appear to be a growth market.

[Itlandm]

The end of episode 3 was a bit confusing. The truth is that even if you had just overcome an "A" influenza, a newly arrived "B" virus might still send your B and T cells flying. This is because these cells tend to become specialized when they fight against virus, and only work against one particular type. So the strength of the virus is not necessarily a big factor.

Also, I am kind of glad they glossed over the part where the macrophage eats the dead cell to find out what kind of virus it contains. Their name means "big eater" because they eat their enemies, often alive. So, not quite as attractive as portrayed in the anime!

[mangamuscle]

Just like in the prior episode, everybody died at the end >_<

Originally Posted by SeijiSensei

I wonder if there will be episodes where drugs or antibiotics are introduced into the body. How about things like "synthetic biotics," ordinary probiotics, or even vitamins? It doesn't sound like the Japanese take vitamins all that much.. Probiotics, on the other hand, appear to be a growth market.

The most popular in japan would be caffeine or whatever they put in those "power" drinks they use to keep working way past the exhaustion threshold.

Originally Posted by Itlandm

The end of episode 3 was a bit confusing. The truth is that even if you had just overcome an "A" influenza, a newly arrived "B" virus might still send your B and T cells flying. This is because these cells tend to become specialized when they fight against virus, and only work against one particular type. So the strength of the virus is not necessarily a big factor.

Don't subestimate Influenza A, since The emergence of a new and very different influenza A virus to infect people can cause an influenza pandemic.. BTW, they forgot to mention influeza type D (to puny to be worthy of mention?)

Also, I am kind of glad they glossed over the part where the macrophage eats the dead cell to find out what kind of virus it contains. Their name means "big eater" because they eat their enemies, often alive. So, not quite as attractive as portrayed in the anime!

Just because is is not shown on camera does not mean she did not, i.e. We all know that Kiss-Shot Acerola-Orion Heart-Under-Blade eats humans whole, but we have never been shown her doing it (and she did about one per week before the "downgrade").

If cells infected by influenza are like zombies, then cancer cells would be what, vampires?

[Lukes YGO & WS on YT]

Spoiler for Episode 3 Comments/Feedback:

White blood cells that become infected wit the flu become zombie like, that's scary, also I didn't think that there would be T blood cells that have scared personalities like that after seeing them in the 1st episode.

Ah we get to see a Macrophage in action, white maids with hatchets, I'm not sure what's scarier, white blood cells with their blood lust or the noble like macrophage.

So all t blood cells are naive at 1st and then become badass, it was funny seeing them all in that memory book, no wonder they all got the chills from it.

Just when you though everyone was fine a Type A shows up, it was kinda funny seeing the flu send the naive cell flying like that.

I had the flu recently so this was cool to see what happens during that time.

[Mangaka-chan]

I'm not sure if I want to call dendritic cell's old photos (aka cytokines) a stroke of genius by the author of call wtf on the whole things. Probably both? It's hilarious, but it makes me question how are stuff like chemokine response gonna be depicted. Like, is DC actually gonna be a mail man and deliver chemokines in the form of letters to immune cells to get them to come to a specific location?

[Dengar]

Don't neutrocils also eat bacteria?

[SeijiSensei]

I continue to smile at the profusion of A-list seiyuu who work on this show. This week we get to hear the ever-17 Inoue Kikuko in the Macrophage role. She, like Noto, can sound like the sweetest woman imaginable yet is horribly dangerous. ANN doesn't yet have the seiyuu for Naive T Cell yet. Anyone know who it was? Were there two voice-actors, one for his wimpy voice, and another for his bad-ass one?

This show is hilarious and for me, who hasn't taken biology in over fifty years, educational. So is this thread. A big thank you to the people here who are sharing their knowledge with us.

[James Rye]

Watching an episode of this show makes time fly by so fast. <3
Poor Naive T-cell, so scared of those Zombie cells and terrorized by his colleges as well. But then he did a Jojo-transformation and kicked Zombie ass! Loved how it showed how all the different parts of the body worked together to overcome the influenza-virus, temperature rising, sweating, muscles contraction to keep the heat in, etc and etc. But in the end they just got a new virus they had to remake the formula against. Tough luck, guys. xD

And next episode: BEST GIRL APPEARS!!! It is a shame we see so little of her, but she is best girl indeed! Such a wonderful, hard-working person! <3 <3 <3