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Old 2018-08-04, 17:12   Link #521
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Join Date: Jan 2008
In 5 years Lab Grown organs could start helping
115,000 in the US waiting for organs:

"Bioengineered lungs have been grown in a Texas lab and transplanted into adult pigs
with no medical complication. This could begin solving the human transplant problem
starting in about 5 years. They could grow lungs to transplant into people in
compassionate use circumstances within five to 10 years."

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Old 2018-08-23, 23:01   Link #522
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Scientists accidentally discover drug that curbs weight gain:

"A pill to prevent obesity is looming on the horizon after the discovery of a protein that
makes people fat.

It would be the “holy grail” of modern medicine – helping reduce the risk of heart
disease, cancer, diabetes and even dementia.

When the enzyme known as CerS1 (ceramide synthase 1) was blocked in mice they
remained lean – even after gorging on high-fat food.

The Australian team behind the breakthrough is hopeful the same will apply to humans."

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Old 2018-09-02, 18:01   Link #523
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Fruit Extract From Amazon Rainforest Prevents Obesity in
Overeating Animals:

"A cherry-like fruit that grows deep in the Amazon jungle has the potential to help
battle the North American obesity crisis, suggests new research published in Gut. In
the study, an extract from camu camu, a round, red, super-tart fruit, reduced obesity
and related illnesses in mice whose diets went otherwise unchanged. The fruit, it
appears, thwarts weight gain before it can start.

Camu camu (Myrciaria dubia) is already advertised in a variety of supplements
because of its insanely high vitamin C content. Until now, however, there hasn’t been
much research on its potential effects on weight management. To investigate this,
Université Laval Quebec Heart and Lung Institute Research Centre researcher André
Marette, Ph.D., first gave one group of mice a high-fat, high-sugar chow until they
were borderline obese and then gave a different group the same food alongside a
dose of camu camu extract. Over the course of eight weeks, the camu camu group
gained 50 percent less weight than the controls, despite their poor dietary habits. In
fact, in some additional experiments, they even lost weight."

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Old 2019-01-09, 00:35   Link #525
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An Implant for Weight Loss, Powered by the Stomach:

"In a recent paper in the journal Nature Communications, engineers at the University of
Wisconsin-Madison (UWM) describe a device to aid weight loss that is less invasive than
surgery and potentially more effective than diets and exercise regimens, which most
people (myself included) struggle to stick with.

The nickel-sized implant, only 1 millimeter (mm) thick, attaches to the outside of the
stomach and uses power generated by stomach movements to subdue feelings of

Rats with the implant shed 38 percent of their body weight over 100 days. Meanwhile,
rats in control groups, which either did not receive the implant or had a sham implant,
did not lose any weight."

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Old 2019-05-08, 23:26   Link #526
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Life extension .......... for dogs!

"George Church describes the roadmap for to human aging reversal treatments

We will see the first aging reversal test in dog trials in the next year or two. If that
works, human trials are another two years away, and eight years before they’re done.
Once you get a few going and succeeding it’s a positive feedback loop.

His company Rejuvenate Bio is actually working on the dog trial now.

The particular dog model we’re using has a heart disease issue. Rejuvenate Bio was still
in semi-stealth mode, incubator mode, but the trial was not a secret. Dogs are a
market in and of themselves. [Tens of billions of dollars per year] It’s not just a big
organism close to humans. It’s something people will pay for. The FDA process is much
faster for dogs than for humans — a little over a year versus nine years or so."

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Old 2019-07-18, 02:14   Link #527
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By Targeting Each Patient's Unique Tumor, Precision Medicine
Is Crushing Once-Untreatable Cancers. But Only a Fraction of
Patients Currently Benefit. Can Medicine Close the Gap?:

"The days when cancer patients received one-size-fits-all regimens of chemotherapy
and radiation may soon be a thing of the past. Instead, doctors are taking a far more
nuanced view of what drugs and treatments will work on which patients and on what
different kinds of cancers. The idea of this so-called precision medicine, or
personalized medicine, is that ultimately doctors will use genetic tests—of both the
patient and the cancer tumor—to determine the exact drugs or treatments that have
the best chance of working.

Although precision-medicine techniques are now being trained on many diseases,
their impact is being felt most strongly in cancer treatment. Researchers are building
a growing list of genes and genetic mutations that show up in tumors and matching
them to drugs that can stop them. The cancer genes that drugs can target now
number in the dozens, and researchers are hot on the trail of hundreds more. For
some cancers once considered virtual death sentences, the outlook is already much
improved: About half of lung-cancer patients respond well to one of the new gene-
matched therapies, and in half of those cases, the cancer doesn't come back. FGFR
inhibitors, the drug that saved Boyed, have shown promise not only in bile duct
cancer but also for some types of bladder, lung, breast and uterine cancers. "We have
six trials open now for FGFR inhibitor drugs alone," says Sameek Roychowdhury, the
oncologist who saved Boyed's life. "By the end of this year there should be 20."

After decades of fits and starts in the field of cancer research, the progress made in
precision medicine is welcome news indeed. But make no mistake: There is no "cure."
Medicine is not even close to bringing cancer to its knees. For patients diagnosed with
advanced cancers—those that have already metastasized, or spread—only one in 10
turn out to have genes currently known to make the cancer susceptible to a new
drug. "Our goal is to give 100 percent of patients a new therapy based on genomic
testing," says Roychowdhury. "But today we don't know how to provide a special
treatment for the results of nine of 10 genomic tests we do.""

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Old 2019-08-25, 15:37   Link #528
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Scientists bioprint living tissue in a matter of seconds:

"Scientists at EPFL and University Medical Center Utrecht have developed an optical
system that can bioprint complex, highly viable living tissue in "just a few seconds." It
would represent a breakthrough compared to the clunky, layer-based processes of

The approach, volumetric bioprinting, forms tissue by projecting a laser down a
spinning tube containing hydrogel full of stem cells. You can shape the resulting tissue
simply by focusing the laser's energy on specific locations to solidify them, creating a
useful 3D shape within seconds. After that, it's a matter of introducing endothelial
cells to add vessels to the tissue.

The resulting tissues are currently just a few inches across. That's still enough to be
"clinically useful," EPFL said, and has already been used to print heart-like valves, a
complex femur part and a meniscus. It can create interlocking structures, too.

While this definitely isn't ready for real-world use, the applications are fairly self-
evident. EPFL imagines a new wave of "personalized, functional" organs produced at
"unprecedented speed." This could be helpful for implants and repairs, and might
greatly reduce the temptation to use animal testing -- you'd just need to produce
organs to simulate effects. This might be as much an ethics breakthrough as it is a
technical one."

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